ABSTRACTS

Submission guidelines

Title/Text

The title should be sentence case of maximum 100 characters. The abstract text is limited to 400 words excluding the title. The abstract allows for one attachments in the form of an image, which could also be an image on tables/graphs.

Author/Speaker

At the end of the submission form, please indicate if you are the author AND the speaker/presenter, or if you are submitting on the author/speaker’s behalf. If you are submitting on their behalf, please provide us with the full name and email address of the author/speaker for proper notification.

Final Submission

Please ensure the accuracy of your contact information AND your organization name (Sister Institution name, or the name of your hospital/university/cancer institute). Incomplete abstracts will not be considered for presentation. Please note, the type of presentation selected (oral or poster) during the submission process is a preference only, and may be changed based the number of abstracts submitted and time allotted per session.
It is the author’s responsibility to submit a correct abstract; any errors in spelling, grammar, or scientific fact will be published as typed by the author, if accepted. Poor English may be a cause for rejection.

Questions

All questions regarding abstracts should be emailed to abstracts.gap2018@appinconf.com .

Deadline

Submission deadline is on January 11, 2018 at 11.59 PM, CET/GMT+1.

 

Scientific breakout session/ workshop (WS) summaries:

WS 1 – Lung cancer

Over the past 5 years, the lung cancer landscape has tremendously evolved. Immunotherapy, targeted agents and the implementation of biomarkers for treatment selection have resulted in improved patient outcome. This section will focus on various aspects of precision medicine for lung cancer, including implementation of treatment decision algorithms, investigation of broader sequencing methods, prognostic and predictive biomarkers as well as novel therapeutics. Attention will also be dedicated to diverse healthcare issues related to lung cancer management, including palliative care.

WS 2 – Pancreatic cancer

Pancreatic cancer is a medical emergency, with the numbers of cancer related deaths rising through the ranks. New approaches encompass both diagnostics and therapy. Blood-based markers will be based on liquid biopsy (ct-DNA, CTC, EV) and also novel protein marker profiles. Applying NGS to CTC bears the prospect of not only diagnosis PDAC but also do the molecular profiling instead of taking a biopsy. Two approaches, more complementing than competing, carry the hope for significant progress in treating PDAC: immunotherapy and precision medicine. The former consists of checkpoint inhibition but also cell based methods with T-cells and CAR. The latter comprises NGS of various extends (panel, WXS) and using artificial intelligence-based software tools to analyse the wealth of mutations in a more holistic way.

WS 3 – Targeting p53 in cancer

The TP53 tumor suppressor gene is the most frequently mutated gene in cancer. Around 50% of human tumors carry mutant TP53. The majority of these mutations are missense mutations that give rise to single amino acid substitutions in the p53 protein. As a result, most mutant p53 proteins in tumors fail to bind specifically to DNA, activate transcription of p53 target genes, and regulate cellular processes such as cell cycle arrest, metabolism and different forms of cell death. In tumors that carry wild type p53, various mechanisms including overexpression of the p53 antagonist Mdm2 can attenuate p53 function. Given the key role of p53 as regulator of cell growht and survival in response to cellular stress, and the high frequency of TP53 mutations in tumors, restoration of normal p53 function appears as an attractive strategy for improved cancer therapy. This session will focus on novel approaches for therapeutic targeting of p53 in cancer.

WS 6 – Breast Cancer

Breast cancer is globally the most common malignancy, with a present annual incidence of 2,4 million. The incidence is rapidly increasing, in particular in previously low incidence regions; should stimulate the usage of prevention strategies. The survival figures for different countries and regions are markedly different. Adjuvant therapies are effective and result in improved outcomes in many countries. Over- and undertreatment remain as key concerns due to the lack of precise therapy predictive factors/ and optimal usage of prognostication strategies. Neoadjuvant therapies, best studied for cytostatics and anti-Her 2 agents, are safe and have a better potential than the corresponding adjuvant therapies, with the potential advantage that non-responding patients can be offered early therapy switches aiming at improving outcomes. The number of advanced breast cancer patients varies markedly between countries and regions. The optimal and tailored therapy in the early and relapse setting require knowledge about the breast cancer biology, in both situations. The access and availability of modern therapies vary markedly in between countries and regions, which is a major challenge for many societies, regions and countries.

WS 8 – Cervical Cancer

Human papillomavirus (HPV) is an extremely common sexually transmitted infection worldwide, with the initial infection occurring in adolescence. Most infections are cleared, however persistent infection with high-risk oncogenic HPV genotypes, e.g. 16 and 18, is the cause of virtually all cervical cancers and annually around 500 000 new cases of cervical cancer occur worldwide. Prophylactic HPV vaccines have been available since 2006 and are very effective if given for prevention prior to infection but do not have effect on pre-existing HPV infections, dysplasias or invasive cancer. Cervical cancer incidence has declined in countries with efficient screening, but this is not the case in countries without screening. The aim of this session is to discuss cervical cancer, with regard to prevention, screening, and management of pre-invasive, invasive disease, including advanced disease.

WS 10 – Clinical Trials in Cancer

The clinical trial process is slow and cumbersome. At the same time, oncology is both blessed and burdened by having the absolute greatest number of INDs (investigational new drugs) in relation to other disciplines in medicine. Advances in trial design and study patient selection have been evident over the past decade: Umbrella, basket, seamless and adaptive clinical trials are now routine. Landmark platform studies like I-Spy and Stampede, using state-of-the art statistics, are models for introducing new drugs and treatment strategies at a more rapid pace. The molecular phenotyping of cancer in clinical trials is rather the rule than the exception. Challenges for the future are many. In early clinical trials, there is a need to incorporate novel imaging and target engagement assays so that Precision Cancer Medicine is more than a patient selection tool. The number of cancer patients participating in clinical trials in both the Nordic countries as well as the United States is very small in relation to the cancer population at large. Endpoints in cancer trials, especially surrogate endpoints and novel endpoints warrant much thought. The 2018 GAP Conference session on clinical trials will be a forum to ventilate ideas and visions so that we are better equipped to facilitate the development of cancer care in the future.

WS 11 – Cancer Progenitor Cells

In this session the cellular origin of cancer will be discussed including the relationship to normal tissue stem cells and to cancer stem cells. Connected topics to be covered are tumour cell plasticity and how such plasticity may be influenced by the progenitor cell niche and cues provided by the tumour microenvironment, the transcriptional and molecular wiring of cancer progenitor cells and implications for tumour evolution and therapeutic strategies.

WS 14 – DNA repair

In this session molecular mechanisms of DNA repair and novel approaches for targeting DNA repair in cancer will be discussed. Focus will be on recent biological and therapeutic advances.

WS 15 – Individualized cancer screening and prevention
Disease areas: Prostate cancer, Breast cancer, Cervical Cancer

Despite successes in the treatment of breast, prostate and cervical cancer the mortality of these diseases is still substantial. We envision that implementation of individualized screening and prevention programs for these cancers will greatly lower mortality due to these diseases. The individualized screening programs will be based on prediction models that stratify persons according to their risk of developing cancer resulting in more efficient use of the existing resources for cancer screening. This would be much better both from an individual point of view as well as from resources’ point of view.

WS 17 – Hematological malignancies

The outcome of patients with hematological malignancies has vastly improved over recent years. More patients live longer and a higher fraction is cured. The session will focus on recent biological and therapeutic advances.